Hemoglobin Albumin Lymphocyte Platelet Score and Prognostic Nutritional Index are Markers of Malignancy in Patients with Elevated Serum Bilirubin Levels
DOI:
https://doi.org/10.64229/9wv59a81Keywords:
Hemoglobin-albumin-lymphocyte-platelet score, Prognostic nutritional index, Malignancy, HyperbilirubinemiaAbstract
Aim: To explore diagnostic role of prognostic nutritional index (PNI) and hemoglobin-albumin-lymphocyte-platelet (HALP) score in patients with hyperbilirubinemia.
Methods: Patients with hyperbilirubinemia divided into malignant and benign groups according to the etiology. PNI and HALP score values of the groups were compared.
Results: Median PNI of the malignant group (38.2 (20.2- 62.3)) was significantly lower than that of the benign group (42 (24.6-78.6)), (p=0.01). HALP scores of the malignant and benign groups were 18.5 (2.1-95.8) and 24.9 (2.9-255), (p=0.03). Considering HALP score, PNI, age, serum triglyceride, HDL-cholesterol, LDL-cholesterol, fibrinogen, GGT, fasting glucose, folic acid, ferritin, total bilirubin and CRP, HALP score remain an independent predictor of malignancy (p=0.004, OR: 0.94, 95%CI: 0.91-0.98). Similarly, PNI was an independent risk factor for malignancy (a unit increase in PNI reduced the malignancy risk by 1% (p=0.003, OR: 0.99, 95%CI: 0.988-0.999)).
Conclusion: Findings of the present study indicate that both HALP and PNI serve as independent predictors of malignancy, even after adjustment for age, lipid profile, and systemic inflammatory and metabolic markers. Higher PNI and HALP levels were associated with a lower risk of malignancy, highlighting the importance of inflammatory and nutritional status during malignant process.
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Copyright (c) 2026 Gulali Aktas, Mehmet Ali Kosekli, Halil Bardak (Author)
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